Not all PRP is platelet rich plasma! Does Platelet Rich Plasma (PRP) Really Work?

Does PRP really work?

01. Results of PRP injections in the face


Human skin ages due to the breakdown of the collagen and elastin layers beneath the skin. This damage is visible in the form of fine lines, wrinkles and creases on the forehead, in the corners of the eyes, between the eyebrows and around the mouth. You may also notice creases at the shoulders. This effect occurs when the structural integrity of collagen fibers is eroded due to internal and external factors. The high concentration of growth factors in the PRP facial repairs collagen and activates fibroblasts, rejuvenating the skin and restoring its youthful appearance.

02. Before and After PRP Hair Treatment



To test the efficacy of PRP for hair loss, doctors performed a hair-plucking test on a random group of patients. They grab about 50 to 60 hairs and pull them away from the scalp. Before treatment, most patients lost about 10 hairs. Repeat the hair pull test after four PRP sessions 6 weeks apart. Patients reported a significant reduction in hair loss with only 3 strands separating from the scalp. In addition, the doctor marks a specific part of the scalp for testing. PRP before and after the test showed about 71 hair follicles and more than 93 hair follicles in the area, respectively.

03. PRP Knee Injection Results



Doctors examine a group of patients with osteoarthritis confirmed by MRI. Each patient received one or two PRP knee injections under the patella. Doctors evaluate their condition at 6-week, 3-month, and 6-month intervals. They found that patients experienced significantly less pain and better mobility during the 6-week to 3-month interval. Knee function also improved significantly. Six months later, the results were much better than before the surgery, although pain and activity levels had not improved further.

04. PRP Review for Acne Scars and Marks



our case

PRP for skin acne treatment

Get out! Acne gentleman

Depending on the severity of the pimple and the damage it caused to the skin, acne scars can come in different varieties, such as box car, ice pick, and rolling car. Inserting PRP up to 1 mm below the scar can help to permanently eliminate acne scars. If needed, the doctor may use fine needles to break up the hardened scar tissue and keloids in the scar so they can respond better to treatment.

Microneedling is another technique used to deliver serum into the skin. Growth factors in PRP serum repair the collagen layer under the skin. Skin gains the appearance of an even tone as this layer produces new cells and plumps over 4 to 6 weeks. Regular follow-up treatments can help further restore the skin.

05. PRP Treatment Reviews for Tendon Injuries



Athletes often suffer from elbow tendon injuries, rotator cuff injuries, and Achilles tendon tears (such as tennis players and runners). Inflammation of the patellar tendon in the knee area is another common injury. In addition to varying degrees of pain, athletes experience swelling, difficulty moving, and a popping sound when moving the affected joint.

Sports injury PRP injections placed on the affected area can help heal new and chronic injuries. After a week of increased swelling immediately following the PRP injection, the patient noted a gradual improvement over the next 5 weeks. By treating hardened scar tissue, PRP serum can speed healing. As a result, pain and inflammation are reduced along with improved mobility.

06. PRP injections for ligament and muscle injuries


Depending on which specific muscles they use more frequently during their sport, professional athletes may see ligament, muscle, and connective tissue injuries. Knee and thigh strains and sprains, as well as strained hamstrings, often cause swelling and difficulty moving. Injecting PRP into the affected muscle can help speed healing. In this way, athletes can shorten recovery time and get back on the field quickly. Doctors who performed PRP before and after the scan showed significant wound healing.

07. PRP Injections Reviews For Infertility



The study was conducted on a group of women over the age of 40. Previous attempts to help them conceive by implanting IVF embryos failed because the lining of the uterus was not thick enough. This condition prevents the implant from integrating into the uterus and can cause a miscarriage. With the help of a combination of PRP injections and hormone supplements, doctors are able to stimulate the development of the lining of the uterus.

PRP treatment helps achieve an optimal thickness of 7mm to 8mm so women are able to carry their pregnancies to term. PRP injections for infertility can also help repair ovaries and uteruses in young women, allowing them to develop and release healthy eggs. Doctors harvested the eggs and prepared them for IVF implantation, resulting in the birth of a healthy baby.

08. PRP dark circles before and after



Aging, environmental factors, lack of sleep and illness can all contribute to the formation of dark circles and puffy eyes. Patients may also notice loose skin under the eyes or what appear to be fluid in eye bags. PRP injections can help with all of these conditions by creating new blood vessels in the delicate skin. These blood vessels nourish the area with fresh oxygen and nutrients and remove accumulated fluid, toxins and impurities.

These before and after PRP results clearly show that skin imperfections such as hyperpigmentation, wrinkles and saggy skin have all disappeared, revealing sparkling eyes. PRP also restores the collagen and elastin layers in the skin, restoring its firmness.

Before and After PRP

These before and after pictures of PRP injections clearly show that when PRP treatment is performed by an expert certified physician, it has the potential to help people with a variety of medical and cosmetic conditions. In addition to the above conditions, PRP is known to aid in wound healing, bone formation and successful tooth implants in dental care and even open heart surgery. In the coming years, PRP therapy may also have various other clinical guidelines for the application of platelet-rich plasma (PRP) in orthopedics to promote bone repair

A fracture is a reakdown of the integrity or continuity of a bone. A fracture that has not healed after 9 months and shows no signs of healing within 3 months is called a nonunion. There are many reasons for delayed fracture union or nonunion, such as bone defect, infection, malnutrition, unstable fixation, and impaired blood supply at the stump.

There are many risk factors for fractures with a long course of disease, delayed union or nonunion, and the treatment is difficult. Delayed union or nonunion of fractures produces pain, loss of function, and psychosocial distortions, resulting in reduced quality of life, inability to work, and reduced income for patients. Find out the risk factors of delayed healing as soon as possible, give timely intervention, and reduce medical expenses. Studies have shown that smoking and diabetes are risk factors for delayed fracture union, and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) can also cause delayed fracture union. In addition, soft tissue injury and vascular disease lead to fracture complications, increasing the risk of delayed union or nonunion.

The use of platelet rich plasma (PRP) improves the therapeutic effect of fracture healing. PRP is derived from autologous whole blood, which is processed in vitro to form a concentrated platelet-containing preparation, which contains a variety of growth factors produced during the natural repair of bone damage. Studies have shown that PRP has the effect of promoting osteogenesis, which can promote the healing and repair of fractures, bone defects, nonunion, osteonecrosis, osteoporosis, spinal disfusion, bone infection and distraction osteogenesis. Clinical practice guidelines are the best tool for clinicians and patients to make clinical decisions, with the ultimate goal of more standardized, rational and efficient diagnosis and treatment of diseases. With the increasing research and application of PRP in the field of orthopedics, new clinical evidence-based medical evidence has been produced in recent years. In order to better regulate the application of PRP in orthopedics, this guideline was developed based on current evidence.

bone repair

Fracture healing and bone tissue repair mainly include two phases:

The first phase is the initial anabolic phase, characterized by the recruitment and differentiation of stem cells to form cancellous bone and blood vessels, and cartilage formation.

The second phase is the catabolic phase, which is characterized by the resorption of cartilage while also serving as a template for the formation of new bone to replace the cartilage. Thereafter, callus tissue is resorbed and the newly formed bone is remodeled into cortical bone in situ.

The overall healing process is a biological effect of associated cell populations and signaling within the regenerating tissue. In the early stage of fracture injury, local tissues produce bioactive substances, which act as local and systemic messengers in the process of bone healing, and have the effect of promoting fracture healing. The abnormality of these biological substances can lead to abnormal bone healing.

PRP growth factor

The bone repairing effect of platelet concentrate may be attributed to the osteogenic growth factors it contains. After the platelets in the concentrated platelets are activated by calcium and/or prothrombin, platelet alpha granules release various growth factors through exocytosis, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor- β (TGF-β), insulin-like growth factor (IGF), epidermal growth factor (EGF), etc., these factors all have osteogenic effects.

vascular endothelial growth factor

It can support and coordinate the early formation of blood vessels and other structures by regulating the migration, proliferation and differentiation of vascular endothelial cells. At the same time, it can stimulate the differentiation of osteoblasts and is a key growth factor in the process of bone repair.

platelet derived growth factor

Platelets aggregated from fracture ends are produced in large quantities and are continuously highly expressed throughout the healing process. They can regulate the migration and proliferation of stem cells, and promote the proliferation and differentiation of osteoblasts.

transforming growth factor-beta

It can induce chemotaxis and mitosis of fibroblasts and osteoblasts, regulate cell growth and proliferation of osteoblasts, induce bone matrix synthesis, remodel extracellular matrix, and promote bone healing. Decrease in TGF-β may be associated with delayed bone union or nonunion.

growth hormone

(growth hormone, GH)/insulin-like growth factor-1 (IGF-1) is associated with delayed bone union or nonunion, and they participate in the proliferation of mesenchymal stem cells, periosteal cells, chondrocytes, osteoblasts, and osteoclasts and differentiation, regulate bone matrix formation, stimulate osteoblasts and chondrocytes to secrete vascular endothelial growth factor, and promote angiogenesis.

Anti-inflammatory effects of PRP

Leukocytes in concentrated platelets induce nuclear factor kB (nuclear factor kappa B, NF-kB) signaling to further amplify the inflammatory response under the action of fibroblasts and osteoblasts. TNF-α, as a key cytokine of inflammatory response, can stimulate the release of TGF-β. TGF-β has immunostimulatory function in the early stage of inflammation or at low concentration, and can gather inflammatory cells; at high concentration, it can inhibit the growth and activity of inflammatory cells such as T, B lymphocytes, and macrophages, and inhibit cytotoxic T cells. Protect the body from immune attack and inhibit the inflammatory response.

Anti-infective effect of PRP

The anti-infective effect of platelet concentrate is mainly based on the platelets and white blood cells it contains. Platelets in concentrated platelets secrete antibacterial peptides, which can destroy bacterial cell membranes, inhibit microbial RNA synthesis, protein synthesis or protein folding, inactivate bacterial toxins, activate bacterial autolysis system, and then exert antibacterial effects. Leukocytes can mediate cellular immunity, activate neutrophils, and engulf pathogenic microorganisms through various cytokines and biological proteins. Studies have shown that concentrated platelets containing a large number of white blood cells can effectively reduce the titer of Staphylococcus aureus. Antibacterial experiments in vitro showed that PPR had antibacterial effects on Staphylococcus aureus, Escherichia coli, Streptococcus agalactiae, and Shigella, but had no effect on Pseudomonas aeruginosa, Klebsiella pneumoniae, and Serratia. The whole blood had no antibacterial effect on the above-mentioned bacteria.


in conclusion

1. Combining concentrated platelets can accelerate fracture healing and shorten hospital stay.

2. It can accelerate the healing of nonunion and shorten the hospital stay.

3. For patients with fractures, nonunions, and bone defects, the use of platelet concentrate will not increase the incidence of adverse events, such as infection, local redness, and swelling.

4. For fixed and stable atrophic nonunion, local injection of platelet concentrate may reduce the probability of reoperation.

5. Concentrated platelets may promote the repair of smoking, diabetic fractures, nonunions, and bone defects.

6. In the treatment of fractures, nonunions, and bone defects combined with infection, leukocyte-enriched platelet concentrate may be better than leukocyte-poor platelet concentrate

Welcome to contact Amain technology Co,.;Ltd, to provide you with a complete set of PRP treatment plan, PRP reagent + PRP blood collection tube.


Joy yu

Amain Technology Co.,Ltd.

Company address:No. 1601, Shidaijingzuo, No. 1533, Middle Section of Jiannan Avenue, High-tech Zone, Sichuan Province

Region Postal Code:610000





Company official website:https://www.amainmed.com/

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Ultrasound website:http://www.amaintech.com/magiq_m

Sichuan Amain Technology Co., Ltd.

Post time: Mar-15-2023

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