NgabaI-PRPumsebenzi ngokwenene?
01. Iziphumo ze-PRP iinaliti ebusweni
Ubudala bolusu lomntu ngenxa yokuqhekeka kwe-collagen kunye ne-elastin layers phantsi kwesikhumba.Lo monakalo ubonakala ngendlela yemigca emihle, imibimbi kunye ne-creases ebunzini, kwiikona zamehlo, phakathi kwamashiya kunye nomlomo.Unokuqaphela nokuqhekeka kwamagxa.Esi siphumo senzeke xa ukunyaniseka kwesakhiwo se-collagen fibers kuchithwa ngenxa yezinto zangaphakathi nangaphandle.Uxinzelelo oluphezulu lwezinto ezikhulayo kwi-PRP yokulungiswa kobuso be-collagen kwaye isebenze i-fibroblasts, ivuselela ulusu kunye nokubuyisela ukubonakala kwayo kobutsha.
02. Ngaphambi nasemva kwe-PRP Unyango lweNwele
Ukuvavanya ukuphumelela kwe-PRP yokulahleka kweenwele, oogqirha benza uvavanyo lokuqhawula iinwele kwiqela elingaqhelekanga lezigulane.Baxhwila iinwele ezimalunga nama-50 ukuya kuma-60 baze bazitsalele kude entloko.Ngaphambi konyango, izigulane ezininzi zalahlekelwa malunga neenwele ze-10.Phinda uvavanyo lweenwele emva kweeseshoni ezine ze-PRP kwiiveki ezi-6 ngaphandle.Izigulane zichaze ukuncipha okuphawulekayo kokulahleka kweenwele kunye nemicu ye-3 kuphela eyahlula kwi-scalp.Ukongezelela, ugqirha uphawula inxalenye ethile ye-scalp yokuvavanya.I-PRP ngaphambi nangemva kovavanyo lubonise malunga neenwele ze-71 kunye neenwele ezingaphezulu kwe-93 kwindawo, ngokulandelanayo.
03. Iziphumo ze-PRP Knee Injection
Oogqirha bahlola iqela lezigulane ezine-osteoarthritis eziqinisekiswe yi-MRI.Isigulane ngasinye safumana i-PRP enye okanye ezimbini iinaliti zedolo phantsi kwepatella.Oogqirha bavavanya imeko yabo kwiiveki ezi-6, kwiinyanga ezi-3, kunye neenyanga ze-6.Bafumene ukuba izigulane zifumana intlungu ephantsi kakhulu kunye nokuhamba okungcono ngexesha le-6-iveki ukuya kwiinyanga ze-3.Umsebenzi wamadolo nawo uphuculwe kakhulu.Kwiinyanga ezintandathu kamva, iziphumo zazingcono kakhulu kunangaphambi kokuhlinzwa, nangona iintlungu kunye namanqanaba omsebenzi awazange aphuculwe ngakumbi.
04. Uphononongo lwe-PRP lweI-Ane Scarskunye namanqaku
ityala lethu
I-PRP yonyango lwe-acne yesikhumba
Phuma!I-acne gentleman
Ngokuxhomekeke kubukhulu beqhakuva kunye nomonakalo owenziwe eluswini, amaqhakuva anokubakho kwiindidi ezahlukeneyo, njengemoto yebhokisi, i-ice pick, kunye ne-rolling car.Ukufaka i-PRP ukuya kwi-1 mm ngaphantsi kwesiva kunokunceda ukuphelisa ngokusisigxina i-acne scars.Ukuba kuyimfuneko, ugqirha unokusebenzisa iinaliti ezicikizekileyo ukuqhekeza izicubu eziqinileyo kunye nee-keloids kwisiva ukuze bakwazi ukuphendula ngcono kunyango.
I-Microneedling yenye indlela esetyenziselwa ukuhambisa i-serum eluswini.Izinto zokukhula kwi-serum ye-PRP zilungisa i-collagen layer phantsi kwesikhumba.Ulusu lufumana imbonakalo yethoni elinganayo njengoko olu maleko luvelisa iiseli ezintsha kwaye luphuphuma ngaphezulu kweeveki ezi-4 ukuya kwezi-6.Unyango olulandelwa rhoqo lunokunceda ngakumbi ukubuyisela ulusu.
05. Uphononongo loNyango lwe-PRP kwiiNzakalo zeTendon
Iimbaleki zihlala zinengxaki yokulimala kwe-elbow tendon, ukulimala kwe-rotator cuff, kunye neenyembezi ze-Achilles tendon (njengabadlali be-tennis kunye nabagijimi).Ukuvuvukala kwe-tendon ye-patellar kwindawo yamadolo yenye inzakalo eqhelekileyo.Ukongeza kwiimpawu ezihlukeneyo zentlungu, abagijimi bafumana ukuvuvukala, ubunzima bokuhamba, kunye nesandi esiphumayo xa uhambisa idibeneyo echaphazelekayo.
Ukulimala kwezemidlalo ii-injection ze-PRP ezibekwe kwindawo echaphazelekayo zinokunceda ukuphilisa ukulimala okutsha kunye nokungapheliyo.Emva kweveki yokwanda kokuvuvukala ngokukhawuleza emva kwenaliti ye-PRP, isigulane saqaphela ukuphuculwa kancinci kwiiveki ezi-5 ezizayo.Ngokuphatha izicubu ezinobunzima, i-PRP serum inokukhawulezisa ukuphilisa.Ngenxa yoko, intlungu kunye nokuvuvukala kuyancitshiswa kunye nokuphucula ukuhamba.
06. I-injection ye-PRP ye-ligament kunye nokulimala kwemisipha
Ngokuxhomekeke kwiziphi izihlunu ezithile abazisebenzisayo rhoqo ngexesha lemidlalo yabo, abadlali bezemidlalo banokubona i-ligament, imisipha kunye nokulimala kwezicubu ezixhumeneyo.Iintambo zedolo kunye nethanga kunye ne-sprains, kunye ne-hamstrings edibeneyo, idla ngokubangela ukuvuvukala kunye nobunzima bokuhamba.Ukujova i-PRP kwi-muscle echaphazelekayo kunokunceda ukuphulukisa ngokukhawuleza.Ngale ndlela, iimbaleki zinganciphisa ixesha lokubuyisela kwaye zibuyele ebaleni ngokukhawuleza.Oogqirha abenza i-PRP ngaphambi nangemva kokuskena babonisa ukuphulukiswa kwesilonda esibalulekileyo.
07. Uphononongo lweeNjongo ze-PRP zokungazali
Uphononongo lwenziwe kwiqela labasetyhini abangaphezu kweminyaka engama-40. Iinzame zangaphambili zokubanceda ukuba bakhawule ngokufakela iimbumba ze-IVF aziphumelelanga ngenxa yokuba ulwelwesi lwesibeleko lwalungekho ngqindilili ngokwaneleyo.Le meko ithintela ukufakwa ekudityanisweni kwesibeleko kwaye kunokubangela ukuphuphuma kwesisu.Ngoncedo lwendibaniselwano ye-PRP ye-injection kunye ne-hormone supplements, oogqirha bayakwazi ukuvuselela ukuphuhliswa kwentambo yesibeleko.
Unyango lwe-PRP lunceda ukufikelela kubukhulu obuphezulu obuyi-7mm ukuya kwi-8mm ukuze abasetyhini bakwazi ukuthwala ukukhulelwa kwabo ixesha elide.Iinaliti ze-PRP zokungabikho komntwana zinokunceda ukulungisa ama-ovari kunye nezibeleko kubasetyhini abancinci, okubavumela ukuba baphuhlise kwaye bakhulule amaqanda aphilileyo.Oogqirha bawavuna amaqanda baza bawalungiselela ukufakwa kwe-IVF, nto leyo eyaphumela ekuzalweni komntwana osempilweni.
08. PRPizangqa ezimnyamaphambi nasemva
Ukuguga, iimeko zokusingqongileyo, ukungabikho kokulala kunye nokugula konke kunokufaka isandla ekubunjweni kwezangqa ezimnyama kunye namehlo akhukhumele.Izigulana zisenokubona ulusu oluxengaxengayo phantsi kwamehlo okanye into ebonakala ilulwelo kwiingxowa zamehlo.Iinaliti ze-PRP zinokunceda kuzo zonke ezi meko ngokudala imithambo yegazi emitsha kulusu oluthambileyo.Le mithambo yegazi yondla indawo ngeoksijini entsha kunye nezondlo kwaye isusa ulwelo oluqokelelweyo, i-toxins kunye nokungcola.
Ezi ziphumo zangaphambi nasemva kwe-PRP zibonisa ngokucacileyo ukuba iziphene zolusu ezifana ne-hyperpigmentation, imibimbi kunye nolusu oluthambileyo zonke ziye zanyamalala, zityhila amehlo aqaqambileyo.I-PRP iphinda ibuyisele i-collagen kunye ne-elastin layers esikhumbeni, ibuyisela ukuqina kwayo.
Ngaphambi nasemva kwe-PRP
Ezi ngaphambi nangemva kwemifanekiso yee-injection ze-PRP zibonisa ngokucacileyo ukuba xa unyango lwe-PRP lwenziwa ngugqirha oqinisekisiweyo oyingcali, lunamandla okunceda abantu abaneemeko ezahlukeneyo zonyango kunye ne-cosmetic.Ukongeza kwezi meko zingentla, i-PRP iyaziwa ngokunceda ekuphulukiseni isilonda, ukubunjwa kwamathambo kunye nokufakelwa kwezinyo eziphumelelayo ekunyamekelweni kwamazinyo kunye nokuhlinzwa kwentliziyo evulekileyo.Kwiminyaka ezayo, unyango lwe-PRP lunokuthi lube nezinye izikhokelo zeklinikhi zokusetyenziswa kweplasma ecebileyo yeplatelet (PRP) kwi-orthopedics ukukhuthaza ukulungiswa kwamathambo.
Ukuqhekeka kukubuyisela kwakhona ingqibelelo okanye ukuqhubeka kwethambo.I-fracture engazange iphole emva kweenyanga ze-9 kwaye ingabonakali iimpawu zokuphulukisa kwiinyanga ze-3 kuthiwa yi-nonunion.Zininzi izizathu zokulibaziseka komanyano lwefracture okanye i-nonnunion, efana ne-bone defect, usulelo, ukungondleki, ukulungiswa okungazinzanga, kunye nokunikezelwa kwegazi kwi-stump.
Kukho izinto ezininzi ezinobungozi bokuphuka kunye nekhosi ende yesifo, ukulibaziseka komanyano okanye ukungabikho, kwaye unyango lunzima.Umanyano olulibazisekileyo okanye ukungabikho kokuqhekeka kuvelisa intlungu, ukulahlekelwa ngumsebenzi, kunye nokuphazamiseka kwengqondo, okukhokelela ekunciphiseni umgangatho wobomi, ukungakwazi ukusebenza, kunye nokunciphisa umvuzo wezigulane.Fumanisa imiba esemngciphekweni yokulibaziseka kokuphiliswa ngokukhawuleza, nceda ungenelele ngexesha, kwaye unciphise iindleko zonyango.Uphononongo lubonise ukuba ukutshaya kunye nesifo seswekile yimiba esemngciphekweni wokulibaziseka komanyano, kwaye ukusetyenziswa kweziyobisi ezichasene nokudumba (NSAIDs) kunokubangela ukulibaziseka komanyano.Ukongezelela, ukulimala kwezicubu ezithambileyo kunye nesifo se-vascular kukhokelela kwiingxaki zokuphuka, ukwandisa umngcipheko wokulibaziseka komanyano okanye ukungabikho.
Ukusetyenziswa kweplasma ecebileyo yeplatelet (PRP) iphucula umphumo wonyango wokuphulukisa ukuphuka.I-PRP ivela kwigazi elipheleleyo le-autologous, elicutshungulwa kwi-vitro ukuze yenze ukulungiswa kweplatelet-concentrated containing, equlethe izinto ezahlukeneyo zokukhula eziveliswa ngexesha lokulungiswa kwendalo komonakalo wamathambo.Ucwaningo luye lwabonisa ukuba i-PRP inempembelelo yokukhuthaza i-osteogenesis, enokukhuthaza ukuphulukiswa nokulungiswa kweefractures, iziphene zamathambo, i-nonunion, i-osteonecrosis, i-osteoporosis, i-spinal disfusion, ukusuleleka kwethambo kunye nokuphazamiseka kwe-osteogenesis.Izikhokelo zeklinikhi zezona zixhobo zingcono kwiiklinikhi kunye nezigulane ukwenza izigqibo zeklinikhi, kunye nenjongo yokugqibela yokuxilongwa ngokusemgangathweni, okunengqiqo kunye nokusebenzayo kunye nokunyangwa kwezifo.Ngokunyuka kophando kunye nokusetyenziswa kwe-PRP kwinkalo ye-orthopedics, ubungqina obutsha bekliniki obusekelwe kubungqina bezonyango buye iveliswa kwiminyaka yamuva.Ukuze kulawulwe ngcono ukusetyenziswa kwe-PRP kwi-orthopedics, esi sikhokelo saphuhliswa ngokusekelwe kubungqina bangoku.
ukulungiswa kwamathambo
Ukuphiliswa koqhekeko kunye nokulungiswa kwethambo lethambo kubandakanya izigaba ezibini:
Isigaba sokuqala sisigaba sokuqala se-anabolic, esibonakaliswe ngokufunwa kunye nokwahlulwa kweeseli ze-stem ukuze zenze ithambo elirhoxisiweyo kunye nemithambo yegazi, kunye nokwakheka kwe-cartilage.
Isigaba sesibini sisigaba se-catabolic, esibonakaliswa yi-resorption ye-cartilage ngelixa lisebenza njengethemplate yokubunjwa kwethambo elitsha lokubuyisela i-cartilage.Emva koko, izicubu ze-callus zihlaziywa kwaye ithambo elisandula ukubunjwa lihlaziywa kwi-cortical bone in situ.
Inkqubo yokuphilisa iyonke yimpembelelo yebhayoloji yeeseli ezihambelanayo kunye nokubonakaliswa ngaphakathi kwezicubu ezivuselelayo.Kwinqanaba lokuqala lokulimala kwamathambo, izicubu zendawo zivelisa izinto eziphilayo, ezisebenza njengezithunywa zendawo kunye nenkqubo kwinkqubo yokuphulukisa amathambo, kwaye ibe nefuthe lokukhuthaza ukuphulukiswa kwe-fracture.Ukungaqhelekanga kwezi zinto zebhayoloji kunokukhokelela ekuphileni okungaqhelekanga kwamathambo.
Ukukhula kwe-PRP
Umphumo wokulungisa amathambo we-platelet concentrate unokubangelwa yi-osteogenic growth factor equlethwe kuyo.Emva kokuba iiplatelet kwiiplatelet ezigxininisiweyo zisebenze nge-calcium kunye / okanye i-prothrombin, i-platelet alpha granules ikhupha izinto ezahlukeneyo zokukhula ngokusebenzisa i-exocytosis, njenge-vascular endothelial growth factor (VEGF), i-platelet-derived growth factor (PDGF), ukuguqula ukukhula kwe-β. (TGF-β), i-insulin-like growth factor (IGF), i-epidermal growth factor (EGF), njl., ezi zinto zonke zineempembelelo ze-osteogenic.
ukukhula kwe-vascular endothelial factor
Inokuxhasa kunye nokulungelelanisa ukubunjwa kwangaphambili kwemithambo yegazi kunye nezinye izakhiwo ngokulawula ukufuduka, ukwanda kunye nokuhlukana kweeseli ze-vascular endothelial.Ngexesha elifanayo, kunokukhuthaza ukuhlukana kwe-osteoblasts kwaye yinto ebalulekileyo yokukhula kwinkqubo yokulungiswa kwamathambo.
iplatelet derived growth factor
Iiplatelets ezidityanisiweyo ukusuka kwiziphelo zokuqhekeka ziveliswa ngobuninzi kwaye zibonakaliswa ngokuqhubekayo kuyo yonke inkqubo yokuphilisa.Bangakwazi ukulawula ukufuduka kunye nokwanda kweeseli ze-stem, kunye nokukhuthaza ukwanda kunye nokuhlukana kwe-osteoblasts.
ukuguqula ukukhula kwe-beta
Inokwenza i-chemotaxis kunye ne-mitosis ye-fibroblasts kunye ne-osteoblasts, ilawule ukukhula kweeseli kunye nokwanda kwee-osteoblasts, ifake i-bone matrix synthesis, ihlaziye i-matrix ye-extracellular, kwaye ikhuthaze ukuphulukiswa kwamathambo.Ukunciphisa kwi-TGF-β kunokudibaniswa nokulibaziseka kwethambo lomanyano okanye ukungabikho.
ihomoni yokukhula
(i-hormone yokukhula, i-GH) / i-insulin-efana ne-factor factor-1 (IGF-1) ihambelana nokulibaziseka kwamathambo okanye i-nonunion, kwaye bathatha inxaxheba ekwandeni kweeseli ze-mesenchymal stem, iiseli ze-periosteal, i-chondrocytes, i-osteoblasts, kunye ne-osteoclasts kunye nokuhlukana. , lawula ukubunjwa kwe-matrix yamathambo, ukuvuselela i-osteoblasts kunye ne-chondrocytes ukukhupha i-vascular endothelial growth factor, kunye nokukhuthaza i-angiogenesis.
Iimpembelelo ezichasayo ze-PRP
I-leukocytes kwiiplatelet ezigxininisiweyo zibangela i-nuclear factor kB (i-nuclear factor kappa B, i-NF-kB) isibonakaliso sokwandisa impendulo yokuvuvukala phantsi kwesenzo se-fibroblasts kunye ne-osteoblasts.I-TNF-α, njenge-cytokine ephambili yempendulo yokuvuvukala, inokukhuthaza ukukhululwa kwe-TGF-β.I-TGF-β inomsebenzi we-immunostimulatory kwinqanaba lokuqala lokuvuvukala okanye kwi-concentration ephantsi, kwaye inokuqokelela iiseli ezivuthayo;ekugxininiseni okuphezulu, kunokuthintela ukukhula kunye nomsebenzi weeseli ezivuthayo ezifana ne-T, i-lymphocytes ye-B, kunye ne-macrophages, kwaye inhibit iiseli ze-cytotoxic T.Khusela umzimba ekuhlaselweni komzimba kwaye uthintele impendulo yokuvuvukala.
Impembelelo ye-Anti-infective ye-PRP
Impembelelo echasene ne-infective ye-platelet concentrate isekelwe ikakhulu kwiiplatelet kunye neeseli ezimhlophe zegazi eziqulethe.Iiplatelets kwiiplatelets ezigxininisiweyo zikhupha iipeptides ezilwa ne-antibacterial, ezinokutshabalalisa iiseli ze-bacterial membranes, inhibit microbial RNA synthesis, iprotein synthesis okanye iprotheni yokusonga, yenza i-toxins yebhaktheriya isebenze, isebenze inkqubo ye-autolysis ye-bacterial, emva koko isebenzise imiphumo yokulwa ne-antibacterial.I-leukocytes inokulungelelanisa ukukhuseleka kweselula, isebenze i-neutrophils, kwaye ifake i-pathogenic microorganisms ngokusebenzisa ii-cytokines ezahlukeneyo kunye neeprotheni ze-biological.Uphononongo lubonise ukuba iiplatelet ezigxininisiweyo eziqulethe inani elikhulu leeseli ezimhlophe zegazi zinokunciphisa ngokufanelekileyo i-titer ye-Staphylococcus aureus.Uvavanyo lwe-antibacterial in vitro lubonise ukuba i-PPR ineempembelelo ze-antibacterial kwi-Staphylococcus aureus, i-Escherichia coli, i-Streptococcus agalactiae, kunye ne-Shigella, kodwa ayizange ibe nefuthe kwi-Pseudomonas aeruginosa, i-Klebsiella pneumoniae kunye ne-Serratia.Igazi lonke lalingenayo impembelelo ye-antibacterial kwiibhaktheriya ezikhankanywe ngasentla.
ukuququmbela
1. Ukudibanisa iiplatelet ezigxininisiweyo kunokukhawuleza ukuphulukiswa kwe-fracture kunye nokunciphisa ukuhlala esibhedlele.
2. Inokukhawuleza ukuphiliswa kwe-nonnunion kunye nokunciphisa ukuhlala esibhedlele.
3. Kwizigulane ezineefractures, i-nonunions, kunye neziphene zamathambo, ukusetyenziswa kwe-platelet concentrate akuyi kwandisa iziganeko ezibi, ezifana nokusuleleka, ubomvu bendawo kunye nokuvuvukala.
4. Kwi-atrophic nonunion esisigxina kunye nezinzileyo, inaliti yendawo ye-platelet concentrate inokunciphisa amathuba okusebenza kwakhona.
5. Iiplatelet ezigxininisiweyo zinokukhuthaza ukulungiswa kokutshaya, ukuphuka kwesifo seswekile, i-nonunions, kunye neziphene zamathambo.
6. Kunyango lweefractures, i-nonunions, kunye neziphene zamathambo ezidityaniswe nokusuleleka, i-leukocyte-enriched platelet concentrate ingaba ngcono kune-leukocyte-poor platelet concentrate.
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