Imininingwane Esheshayo
Ikhasethi Lokuhlola I-Dengue Combo (Igazi Eliphelele/I-Serum/Plasma) ukuhlolwa kwe-chromatographic okusheshayo kokutholwa kwekhwalithi yama-antigen e-NS1 kanye ne-IgG kanye ne-IgM yegciwane leDengue egazini lonke lomuntu, i-serum, noma i-plasma njengosizo ekuxilongweni koDengue. izifo.
Ukupakisha Nokulethwa
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Imininingwane
AMRDT001 Dengue Combo Rapid Test Cassette
Ikhasethi Lokuhlola I-Dengue Combo (Igazi Eliphelele/I-Serum/Plasma) ukuhlolwa kwe-chromatographic okusheshayo kokutholwa kwekhwalithi yama-antigen e-NS1 kanye ne-IgG kanye ne-IgM yegciwane leDengue egazini lonke lomuntu, i-serum, noma i-plasma njengosizo ekuxilongweni koDengue. izifo.
Udenga yi-flavivirus, esakazwa omiyane i-Aedes aegypti kanye ne-Aedes albopictus.Isatshalaliswa kabanzi ezindaweni ezishisayo nezishisayo emhlabeni wonke,1 futhi ibangela izifo ezifika ezigidini eziyi-100 ngonyaka.2 Ukutheleleka kodenga oluvamile kubonakala ngokuqubuka komkhuhlane, ikhanda elibuhlungu elibuhlungu, i-myalgia, i-arthralgia kanye nokuqubuka.Ukutheleleka kweDengue okuyisisekelo kubangela ukuthi amasosha omzimba e-IgM akhuphuke aze afike ezingeni elibonakalayo ezinsukwini ezi-3 kuya kweziyi-5 ngemva kokuqala komkhuhlane.Amasosha omzimba e-IgM ngokuvamile aphikelela ezinsukwini ezingu-30 kuya kwezingu-90. 3 Iziguli eziningi zoDengue ezifundeni eziwumkhuhlane zinokutheleleka kwesibili,4 okuholela emazingeni aphezulu amasosha omzimba athile e-IgG ngaphambi noma kanyekanye nokuphendula kwe-IgM.5 Ngakho-ke, ukutholakala kwe-anti-Dengue IgM ethile kanye Amasosha omzimba e-IgG angasiza futhi ukuhlukanisa phakathi kokutheleleka okuyisisekelo kanye nesesibili.I-NS1 ingenye ye-7 Dengue Virus non-structural proteins okucatshangwa ukuthi iyabandakanyeka ekuphindaphindeni kwegciwane.I-NS1 ikhona njenge-monomer ngendlela yayo engavuthiwe kodwa icutshungulwa ngokushesha ku-endoplasmic reticulum ukuze yakhe i-dimer ezinzile.Inani elincane le-NS1 lihlala lihlotshaniswa ne-intracellular organelles lapho kucatshangwa ukuthi libandakanyeka ekuphindaphindeni kwegciwane.Enye ingxenye ye-NS1 itholakala ihlotshaniswa nolwelwesi lwe-plasma noma ifihliwe njenge-hexadimer encibilikayo.I-NS1 ibalulekile ekusebenzeni kwegciwane kodwa ukusebenza kwayo okunembayo kwebhayoloji akwaziwa.Amasosha omzimba aphakanyiswe ukuphendula i-NS1 ekuthelelekeni ngegciwane angakwazi ukuhlangana nama-antigen angaphezulu kweseli kumaseli e-epithelial nama-platelet futhi lokhu kuye kwaba nomthelela ekwakhiweni kwe-Dengue Hemorrhagic fever.
AMRDT001 Dengue Combo Rapid Test Cassette
I-Dengue IgG/IgM Rapid Test Cassette (Igazi Eliphelele/iSerum/Plasma) iyi-immunoassay esekelwe kulwelwesi esezingeni ukuze kutholwe amasosha omzimba oDengue egazini lonke, i-serum, noma i-plasma.Lokhu kuhlola kuqukethe izingxenye ezimbili, ingxenye ye-IgG kanye nengxenye ye-IgM.Engxenyeni ye-IgG, i-IgG ephikisana nomuntu ifakwe endaweni yomugqa wokuhlola we-IgG.Ngesikhathi sokuhlolwa, isampula sibhekana nezinhlayiya ze-Dengue antigen-coated kukhasethi lokuhlola.Ingxube ibe isithuthela phezulu kulwelwesi lwe-chromatographical ngesenzo se-capillary futhi isabela ne-IgG emelene nomuntu endaweni yokuhlola ye-IgG.Uma isifanekiso siqukethe amasosha omzimba e-IgG kuDengue, kuzovela umugqa onemibala endaweni yokuhlola ye-IgG.Engxenyeni ye-IgM, i-IgM ephikisana nomuntu ihlanganiswe esifundeni somugqa wokuhlola we-IgM.Ngesikhathi sokuhlolwa, isifanekiso siphendula nge-IgM ephikisana nomuntu.Amasosha omzimba kaDengue IgM, uma ekhona esibonelweni, asabela ne-IgM emelene nomuntu kanye nezinhlayiya ze-Dengue antigen-coated kukhasethi lokuhlola, futhi le nkimbinkimbi ithwetshulwa i-IgM emelene nomuntu, yakhe umugqa onemibala esifundeni somugqa wokuhlola we-IgM. .Ngakho-ke, uma isifanekiso siqukethe amasosha omzimba kaDengue IgG, kuzovela umugqa onemibala endaweni yokuhlola ye-IgG.Uma isifanekiso siqukethe amasosha omzimba kaDengue IgM, umugqa onemibala uzovela esifundeni somugqa wokuhlola we-IgM.Uma isifanekiso singaqukethe amasosha omzimba oDengue, awukho umugqa onemibala ozovela kunoma yisiphi isifunda somugqa wokuhlola, okubonisa umphumela ongemuhle.Ukuze usebenze njengokulawula kwenqubo, umugqa onemibala uzohlala uvela esifundeni somugqa wokulawula, okubonisa ukuthi umthamo ofanele we-specimen ungeziwe futhi i-membrane wicking yenzekile.
AMRDT001 Dengue Combo Rapid Test Cassette
I-Dengue NS1 Rapid Test Cassette (Igazi Eliphelele/iSerum/Plasma) iyi-immunoassay esekelwe kulwelwesi esezingeni ukuze kutholwe i-Dengue NS1 antigen egazini lonke, i-serum, noma i-plasma.Ngesikhathi sokuhlolwa, isifanekiso sisabela nge-Dengue antibody-conjugate kukhasethi lokuhlola.I-Gold antibody conjugate izobophezela ku-Dengue antigen kusampula yesampula ezobopha ne-Anti-Dengue NS1 embozwe kulwelwesi.Njengoba i-reagent ihamba yonkana kulwelwesi, i-antibody ye-Dengue NS1 kulwelwesi izobopha inkimbinkimbi ye-antibody-antigen ebangela umugqa ophinki ophaphathekile noma omnyama wakheke esifundeni somugqa wokuhlola wolwelwesi lokuhlola.Ukuqina kwemigqa kuzohluka kuye ngenani le-antigen elikhona kusampula.Ukubonakala komugqa opinki endaweni yokuhlola kufanele kubhekwe njengomphumela omuhle.【AMA-REAGENTS】Ikhasethi Lokuhlola Okusheshayo Lodenga Lodenga IgG/IgM liqukethe izinhlayiya ze-Dengue antigen conjugated gold colloid, i-IgM ephikisana nomuntu, i-IgG emelene nomuntu ehuqwe kulwelwesi.I-Dengue NS1 Rapid Test Cassette iqukethe izinhlayiya ezilwa noDengue Ag conjugated colloid, anti-Dengue Ag embozwe kulwelwesi.
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